When Is Mlb Opening Day 2025 Season. The official start date for the 2025 mlb season is march 18, 2025, as the dodgers will face the chicago cubs. He could dominate mlb in 2025, starting with opening day, march 27 against the marlins in miami.

From the tokyo series and opening day through the end of the regular season, here are the key dates to know on the 2025 mlb schedule. The 2025 regular season will be concluded on sunday 28 september.